What Is MassZymes?
MassZymes is a full-spectrum digestive enzyme supplement from BIOptimizers designed to help break down protein, carbohydrates, fats, fiber, lactose, and other components of food.
Its biggest point of differentiation is potency—particularly when it comes to protein digestion.
The current formula contains 18 digestive enzymes, including five different proteases providing 100,000 HUT of protease activity per capsule. It also includes AstraZyme™, a proprietary botanical complex derived from Panax ginseng and Astragalus membranaceus.
Each bottle contains 120 vegetable capsules, and the formula is vegan-friendly as well as free from gluten and soy.
MassZymes also comes from a more established supplement company than many products commonly encountered through affiliate marketplaces. BIOptimizers traces its history back to 2004, today sells a broad portfolio covering digestion, magnesium, probiotics, metabolic health, sleep, and other wellness categories, and describes MassZymes as one of its best-selling products.
For consumers interested in digestive optimization—and particularly active adults consuming substantial amounts of protein—MassZymes has a clear and unusually focused formulation strategy.
Why Digestive Enzymes Matter
Digestion depends heavily on enzymes.
Proteases break proteins into smaller peptides and amino acids. Lipases help digest dietary fats, while amylases help break carbohydrates into simpler molecules that can ultimately be absorbed.
Other enzymes have more specialized roles.
Lactase helps digest lactose. Alpha-galactosidase acts on certain complex carbohydrates found in foods such as beans and vegetables, while cellulase and related enzymes help break down components of plant foods that human digestive enzymes don’t handle efficiently on their own.
This provides the basic rationale for digestive enzyme supplementation: give the digestive process additional enzymatic activity at the same time food needs to be broken down.
MassZymes takes that concept considerably further than a basic three-enzyme product.
What’s Inside MassZymes?
Five-Protease Blend
Protein digestion is where MassZymes places its greatest emphasis.
According to the current product information, each capsule provides 100,000 HUT of protease activity across five different proteases. The rationale for using several proteases is to provide activity across different pH conditions encountered during digestion.
That makes the formula particularly interesting for people consuming protein-rich meals, protein shakes, or higher-protein diets.
It is also important to distinguish enzyme activity units from simple ingredient weight. For digestive enzymes, a milligram number alone doesn’t necessarily tell consumers how much catalytic activity they’re getting. Units such as HUT provide more useful information about enzyme activity.
Amylase and Glucoamylase
Amylase helps break down starches and other complex carbohydrates, while glucoamylase assists with further carbohydrate breakdown.
Together, they broaden MassZymes beyond its protein-focused positioning.
Lipase
Lipase helps break dietary triglycerides into smaller components that can be absorbed.
Its inclusion means MassZymes addresses all three major macronutrient groups: protein, carbohydrates, and fat.
Lactase
Lactase breaks lactose into simpler sugars.
This makes it a useful addition to a full-spectrum enzyme formula, particularly for people whose meals contain dairy. However, having lactase in the formula shouldn’t be interpreted as evidence that MassZymes will fully compensate for clinically significant lactose intolerance in every user.
Alpha-Galactosidase
Alpha-galactosidase helps break down certain complex carbohydrates that can otherwise be fermented by intestinal bacteria.
That’s particularly relevant to foods such as legumes and some vegetables and provides a logical connection between the enzyme and post-meal gas or bloating.
Plant-Food and Fiber Enzymes
MassZymes also includes cellulase, hemicellulase, beta-glucanase, pectinase and xylanase.
These enzymes expand the formula’s ability to act on different structural carbohydrates and plant-food components.
For people eating a diverse whole-food diet, that makes MassZymes more comprehensive than an enzyme supplement built solely around protease, lipase, and amylase.
AstraZyme™
AstraZyme™ is a proprietary combination derived from Panax ginseng and Astragalus membranaceus.
BIOptimizers positions it as an absorption-enhancing component of MassZymes and cites laboratory research suggesting effects on the uptake of several nutrients.
This is an interesting formulation addition, but the distinction between laboratory evidence and demonstrated real-world outcomes is important. The sales presentation makes aggressive claims about percentage increases in nutrient and amino-acid absorption that shouldn’t automatically be interpreted as equivalent improvements in muscle growth, recovery, or physical performance.
We see AstraZyme™ as an interesting supporting component, while the high-potency multi-enzyme profile remains the strongest reason to consider MassZymes.
What Does the Science Say About Digestive Enzyme Supplementation?
There is a straightforward physiological basis for digestive enzymes: these molecules participate directly in breaking food into components that can be absorbed.
The more useful consumer question is whether supplemental enzymes can produce noticeable benefits when a person’s own digestive system is already producing enzymes.
Human research suggests that multi-enzyme supplementation can be useful in some circumstances.
Multi-Enzyme Formulas Have Human Clinical Evidence
A randomized, double-blind, placebo-controlled clinical trial published in 2023 evaluated a multi-enzyme preparation in 120 adults with functional dyspepsia.
Participants received either two capsules daily of a fungal-fermentation-derived multi-enzyme preparation or placebo for two months.
The enzyme group experienced improvements in dyspepsia-related quality-of-life scores, pain severity, and sleep-quality measures, and the preparation was reported as well tolerated.
An earlier multicenter randomized double-blind study involving 203 people with dyspeptic symptoms also found digestive enzyme preparations effective and generally well tolerated during the study period.
These studies don’t prove that every healthy person needs supplemental enzymes, nor did they evaluate MassZymes specifically.
What they do establish is that multi-enzyme supplementation is a legitimate area of human clinical research, particularly when digestive symptoms are present.
Protein Digestion Is MassZymes’ Strongest Formulation Argument
MassZymes goes beyond general digestive support by placing unusually strong emphasis on protease.
That makes sense for its original audience of athletes, bodybuilders, and people consuming protein-heavy diets.
Protein must be broken into peptides and amino acids before those components can be absorbed. Proteases are directly involved in that process.
Where we would be more cautious is with some of the sales page’s more dramatic extrapolations.
The page itself acknowledges that its headline about turning “1 gram of protein into 3 grams” isn’t literally possible. It also makes strong claims about muscle growth, recovery, amino-acid absorption, energy, and the amount of protein people normally absorb.
We don’t think those claims are necessary to make MassZymes interesting.
A high-activity, broad-spectrum digestive enzyme formula already has a reasonable purpose without assuming that it will multiply the muscle-building value of someone’s protein intake.
What About the Complete MassZymes Formula?
Based on the research we reviewed, we did not identify a published randomized, placebo-controlled clinical trial evaluating the complete current MassZymes formula as sold to consumers.
The evidence therefore supports digestive enzyme supplementation as a category and the physiological roles of the individual enzymes more strongly than it establishes specific clinical outcomes from MassZymes itself.
That distinction doesn’t undermine the product’s core proposition.
MassZymes contains enzymes that directly participate in food digestion, uses a broad spectrum rather than relying on one or two enzymes, and discloses substantial protease activity.
For a digestive enzyme product, those are meaningful formulation qualities.
What Are the Potential Advantages of MassZymes?
MassZymes has several characteristics that stand out:
- 18-enzyme full-spectrum formula
- Five different proteases
- 100,000 HUT of protease activity per capsule
- Enzymes targeting proteins, fats, carbohydrates, lactose, fiber, and other food components
- Particularly relevant to higher-protein diets
- Includes AstraZyme™ as an additional absorption-focused component
- Vegan and vegetarian friendly
- Gluten-free and soy-free
- 120 vegetable capsules per bottle
- Produced by an established supplement company with a broad product portfolio
- 365-day money-back guarantee
- Significant unit-price savings with larger ClickBank packages
We especially like that MassZymes isn’t simply a generic “digestive blend.”
Its emphasis on enzyme activity and multiple proteases gives the formula a specific technical identity, while the broader enzyme spectrum makes it useful beyond protein digestion alone.
What Should You Consider Before Buying?
Not everyone necessarily needs a high-potency digestive enzyme supplement.
Healthy digestion already involves enzymes produced by the pancreas, stomach, and small intestine, among other sources. A supplement shouldn’t automatically be viewed as correcting an “enzyme deficiency” simply because someone experiences occasional digestive discomfort.
Persistent bloating, unexplained weight loss, chronic diarrhea, significant abdominal pain, blood in the stool, or major changes in digestive function deserve appropriate evaluation rather than simply increasing digestive enzyme intake.
The MassZymes sales page also uses unusually aggressive bodybuilding-oriented marketing language. Claims about dramatically multiplying protein utilization, accelerating muscle growth, or producing large improvements in recovery should be separated from the much more defensible proposition that supplemental enzymes can assist with the breakdown of food.
Another practical consideration is dosage.
Because MassZymes can be used around meals and dosage may vary with meal size and individual needs, a 120-capsule bottle doesn’t necessarily represent the same number of days for every user. Someone taking several capsules with multiple meals will naturally go through a bottle faster.
MassZymes Pricing & Packages
At the time of our review, the ClickBank offer reviewed for this article presented the following one-time package pricing:
| Package | Quantity | Price | Advertised Unit Price |
|---|---|---|---|
| 1 Bottle | 120 Capsules | $69 | $69/bottle |
| 3 Bottles | 360 Capsules | $177 | $59/bottle |
| 6 Bottles | 720 Capsules | $297 | $49.50/bottle |
The ClickBank sales page confirms the $69 single bottle, $177 three-bottle package, and $297 six-bottle package.
The six-bottle option lowers the unit price from $69 to $49.50 per bottle, a reduction of about 28% compared with purchasing a single bottle at the advertised ClickBank price.
The three-bottle package sits at $59 per bottle and requires a considerably smaller upfront commitment than the $297 six-bottle option.
We were not able to reliably verify current U.S. shipping charges for these specific ClickBank packages, so we haven’t labeled any of them as free shipping. Shipping should be confirmed during checkout before completing the order.
It’s also worth knowing that BIOptimizers operates its own e-commerce store with different MassZymes pricing, package configurations, promotions, and subscription options. Those offers shouldn’t be confused with the ClickBank offer evaluated here.
The 365-Day Money-Back Guarantee: An Important Distinction
A 365-day guarantee is unusually long for a dietary supplement and initially looks like one of MassZymes’ strongest purchasing advantages.
There is, however, an important condition consumers need to understand.
BIOptimizers’ current guarantee language says customers can return their remaining unopened bottles within the 365-day period for a refund, minus shipping and handling. It also states that opening a second bottle disqualifies the purchase from the guarantee.
The ClickBank MassZymes sales page uses essentially the same condition: after trying the first bottle, dissatisfied customers are instructed to return the remaining unopened bottles, and it specifically states that opening a second bottle ends guarantee eligibility.
This makes the guarantee substantially different from an unrestricted 365-day trial of the entire order.
For example, someone buying six bottles shouldn’t interpret the policy as permission to use MassZymes for eleven months and then return the final bottle if dissatisfied.
The practical benefit is instead that you have a very long calendar window in which to evaluate the first bottle without having to rush your decision.
That’s still valuable purchase protection, but understanding the unopened-bottle requirement before ordering is important.
Is MassZymes a Subscription?
The ClickBank sales presentation includes an optional Loyalty Savings Club that operates as a recurring subscription.
According to the sales page, customers enrolled in that program receive future MassZymes shipments every 30 days and are automatically charged until they cancel. Cancellation is available without penalty, but the company asks customers to contact support at least 48 hours before the next order processes.
BIOptimizers’ own store also currently offers both Subscribe & Save and one-time purchase options, with pricing that differs from the ClickBank funnel.
Because multiple purchasing paths exist, we recommend checking the final checkout page carefully to confirm whether you’re selecting a one-time package or recurring program before submitting payment.
Who Is BIOptimizers?
The company behind a supplement matters—particularly when a product is sold online.
BIOptimizers has a substantially broader commercial presence than a typical single-product supplement brand.
The company traces its history to 2004 and today markets a wide range of products covering digestive enzymes, probiotics, magnesium, sleep, metabolic wellness, brain support, and other categories. Its current corporate materials describe approximately 20 years of research and tens of thousands of internal laboratory tests.
Its website also lists a broad group of health, fitness, and wellness personalities associated with the brand, including Paul Chek, Dave Asprey, Ben Greenfield, Dr. Caroline Leaf, Max Lugavere, and Dr. Mindy Pelz.
The MassZymes sales page specifically includes an endorsement from Paul Chek, founder of the CHEK Institute, describing his personal experience with BIOptimizers products.
These endorsements aren’t clinical evidence, of course.
What the company’s longevity, product catalog, and established commercial presence do provide is greater brand context and accountability than we typically see with supplements built around a single temporary sales funnel.
What Are Customers Saying About BIOptimizers?
Because BIOptimizers sells many different supplements, company-level customer reviews shouldn’t be treated as MassZymes-specific effectiveness data.
They can, however, tell us something about the broader purchasing and customer-service experience.
At the time of our review, BIOptimizers had 535 reviews and a 2.5/5 TrustScore on Trustpilot. The distribution was unusually polarized: 62% of reviewers gave the company five stars, while 11% gave it one star.
Positive feedback includes reports of satisfaction with various BIOptimizers products, including some customers specifically mentioning digestive enzymes and improved digestive experiences.
Negative reviews more often raise concerns about subscriptions, customer service, shipping, refunds, or individual products not producing the expected results. BIOptimizers responds to negative reviews on the platform and, according to Trustpilot, had responded to 100% of negative reviews at the time we checked.
The company’s own MassZymes storefront presents a much more positive customer picture, with hundreds of product reviews and ratings above four stars on some regional BIOptimizers sites. Because those reviews are hosted by the seller, we treat them separately from independent platforms.
Our takeaway is straightforward: MassZymes comes from an established company with substantial commercial history, but independent customer feedback shows that the purchasing and service experience isn’t universally positive.
That makes understanding the guarantee and any subscription terms particularly worthwhile.
Who Is MassZymes Best For?
MassZymes may be especially appealing to:
- Adults interested in full-spectrum digestive enzyme support
- People who experience occasional post-meal heaviness or bloating
- Athletes and active adults consuming higher-protein diets
- People who regularly use protein shakes or protein-rich meals
- Consumers looking for enzymes covering protein, carbohydrates, fats, lactose, and plant-food components
- Vegans and vegetarians seeking a plant-based enzyme formula
- Consumers who value clearly stated enzyme activity rather than ingredient names alone
It may be more product than necessary for someone who already digests a varied diet comfortably and has no particular interest in supplemental digestive support.
Pros & Cons
Pros
- Comprehensive 18-enzyme formula
- Five different proteases
- 100,000 HUT protease activity per capsule
- Supports digestion of all three major macronutrients
- Additional enzymes target lactose and complex plant carbohydrates
- Particularly interesting for higher-protein diets
- Vegan and vegetarian friendly
- Gluten-free and soy-free
- 120 vegetable capsules per bottle
- Established manufacturer with a broad supplement portfolio
- Unusually long 365-day guarantee window
- Larger ClickBank packages significantly reduce the cost per bottle
Cons
- Some sales-page muscle-building and protein-absorption claims are considerably stronger than the clinical evidence supports
- Opening a second bottle voids eligibility for the 365-day guarantee
- U.S. shipping cost for the specific ClickBank offer wasn’t clearly verified
- Number of days per bottle varies substantially depending on dosage
- Multiple purchasing channels and subscription options require attention at checkout
- Independent BIOptimizers customer feedback is mixed
Final Verdict
MassZymes is one of the more technically interesting digestive enzyme supplements we’ve reviewed.
Its strongest quality isn’t a dramatic promise about turning protein into muscle. It’s the breadth and potency of the enzyme formula itself.
Eighteen digestive enzymes, five forms of protease, 100,000 HUT of protease activity per capsule, and coverage spanning protein, fats, carbohydrates, lactose, and several plant-food components give MassZymes a clearly defined formulation strategy.
There is also human clinical evidence supporting multi-enzyme supplementation for certain digestive symptoms, although that research shouldn’t be mistaken for a clinical trial of MassZymes itself. The AstraZyme™ component is interesting, but we give more weight to the established physiological roles of the digestive enzymes than to the sales page’s more ambitious absorption and muscle-building claims.
BIOptimizers’ history is another positive. A company operating since 2004 with a broad supplement catalog and established direct-to-consumer business gives MassZymes more commercial context than many single-product affiliate offers. That doesn’t prove effectiveness, but it matters when evaluating who stands behind the product.
The 365-day guarantee is also unusually generous in duration, but consumers should understand its most important restriction: the policy is essentially designed to let you evaluate the first bottle. Opening a second bottle removes guarantee eligibility.
For pricing, the three-bottle package at $177 offers a reasonable middle ground, while the six-bottle package provides the lowest ClickBank unit price at $49.50. Because we couldn’t reliably verify shipping for these particular packages, that cost should be checked at checkout.
For adults interested in serious digestive enzyme support—particularly active people consuming protein-rich diets—we think MassZymes is a strong option to consider.
Its formula gives us more substantive reasons for that conclusion than its more aggressive marketing claims do.
Frequently Asked Questions
MassZymes is a full-spectrum digestive enzyme supplement from BIOptimizers containing 18 digestive enzymes, including five proteases, plus AstraZyme™. It is designed to support the breakdown of protein, carbohydrates, fats, lactose, and other food components.
What is MassZymes? MassZymes is a full-spectrum digestive enzyme supplement from BIOptimizers containing 18 digestive enzymes, including five proteases, plus AstraZyme™. It is designed to support the breakdown of protein, carbohydrates, fats, lactose, and other food components.
How many capsules are in a bottle of MassZymes?
Yes. MassZymes uses non-animal enzyme sources and vegetable capsules and is marketed as vegan and vegetarian friendly. The current product information also identifies it as gluten-free and soy-free.
Its biggest distinction is its emphasis on protein digestion. MassZymes provides five proteases and 100,000 HUT of protease activity per capsule while also including enzymes for fats, carbohydrates, lactose, fiber, and other plant-food components.
Digestive enzyme supplementation has shown benefits for digestive symptoms in some human clinical research, and MassZymes contains enzymes that act on several food components associated with digestive discomfort.
That doesn’t mean all bloating is caused by inadequate digestive enzymes, however. Persistent or unexplained bloating can have many causes and deserves appropriate evaluation.
No. Although the ClickBank sales page strongly targets athletes and high-protein diets, the formula is fundamentally a full-spectrum digestive enzyme supplement and can be relevant to other adults interested in supporting food digestion.
In the ClickBank offer reviewed for this article, one bottle costs $69, three bottles cost $177 ($59 each), and six bottles cost $297 ($49.50 each). We weren’t able to reliably confirm U.S. shipping charges for these specific packages.
BIOptimizers provides a 365-day money-back guarantee, but an important restriction applies: customers can try the first bottle and return their remaining unopened bottles. Opening a second bottle makes the purchase ineligible for the guarantee. Shipping and handling aren’t refunded under the current BIOptimizers policy.
Sources & References
Official Product Sources
1. BIOptimizers — MassZymes ClickBank Sales Presentation
Source for the ClickBank offer, product positioning, protease activity, AstraZyme™, package pricing, guarantee, endorsements, and Loyalty Savings Club.
2. MassZymes — Refund Policy
Official refund-policy destination supplied for this review.
3. BIOptimizers — MassZymes Product Information
Current manufacturer information about the formula, enzyme profile, dietary characteristics, and broader product positioning.
4. BIOptimizers — About the Company
Background on BIOptimizers, its research positioning, product portfolio, and health and performance personalities associated with the brand.
Scientific & Independent Sources
5. Efficacy of Digestive Enzyme Supplementation in Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
A 2023 randomized trial involving 120 participants evaluated a fungal-fermentation-derived multi-enzyme preparation for two months. The enzyme group experienced improvements across several dyspepsia-related measures compared with placebo.
6. Efficacy of Compound Digestive Enzyme Tablet for Dyspeptic Symptoms: A Randomized Double-Blind Multicenter Clinical Trial
A randomized multicenter study involving 203 participants found both digestive-enzyme preparations evaluated to be effective and generally well tolerated for dyspeptic symptoms.
Independent Customer Feedback
7. Trustpilot — BIOptimizers Reviews
At the time of our review, BIOptimizers had 535 reviews and a 2.5/5 TrustScore. Customer experiences are mixed and cover the company’s broader product portfolio rather than MassZymes alone, so we use this source primarily to evaluate purchasing and customer-service patterns—not clinical effectiveness.
View BIOptimizers Reviews on Trustpilot
Research involving digestive enzymes as a category helps us evaluate the scientific rationale behind MassZymes, but studies of other multi-enzyme preparations do not establish how the complete MassZymes formula will perform for every individual. Manufacturer endorsements and customer reviews likewise describe commercial or individual experiences and should not be interpreted as clinical evidence.
